89 articles - From Friday Sep 02 2022 to Friday Sep 09 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
| Clin Gastroenterol Hepatol |
AGA Clinical Practice Update on the Evaluation and Management of Acute Kidney Injury in Patients with Cirrhosis: Expert Review. These Best Practice Advice (BPA) statements were drawn from a review of the published literature and from expert opinion. Since systematic reviews were not performed, these BPA statements do not carry formal ratings of the quality of evidence or strength of the presented considerations. |
meta-analyses and systematic reviews
| Endoscopy |
Learning Curve for Esophageal Peroral Endoscopic Myotomy: A Systematic Review and Meta-Analysis. Our analysis shows that new adopters of POEM with previous advanced endoscopy experience will require about 25 procedures to attain proficiency. The average time for each procedure once proficiency is attained is about 85 minutes. |
RCT, clinical trials, retrospective studies, etc…
| Am J Gastroenterol |
Effects of bowel training and defecation posture on chronic constipation in older adults with dementia: A randomized controlled trial. Defecation care, including bowel training and appropriate defecation posture, is effective for CC among older adults with dementia, improving patient mental health, and reducing the burden on caregivers. |
Provider beliefs, practices, and perceived barriers to dietary elimination therapy in eosinophilic esophagitis. With less access to dietitians (56%), non-academic providers often manage diets without dietitian guidance (41%). CONCLUSIONS: Given high patient acceptance for diets and multiple treatment options for EoE, clinicians need evidence-based knowledge on EoE diets, access to dietitians, and awareness of patient preferences. |
| Clin Gastroenterol Hepatol |
A Prospective Cohort Study Evaluating PAN-PROMISE, a Patient-Reported Outcome Measure To Detect Post-ERCP Morbidity. Future studies are needed to characterize better the reasons behind this increase in symptoms and potential interventions to reduce the symptom burden post-ERCP. gov number, NCT05310409. |
Complete endoscopic healing is associated with a lower relapse risk after anti-TNF withdrawal in inflammatory bowel disease. The relapse risk was high after anti-TNF withdrawal in IBD patients with endoscopic healing, but remission was regained in most cases after anti-TNF reintroduction. Complete endoscopic healing, and mesalamine treatment in UC/IBDU patients, decreased the risk of relapse. |
DEVELOPMENT AND VALIDATION OF A NATIONAL US ACHALASIA COHORT: THE VETERANS AFFAIRS ACHALASIA COHORT (VA-AC). Using a rigorous validation approach, we established a national cohort of 2,100 individuals with achalasia within the VHA, one of the largest established to date. This cohort can be utilized to study risk factors for achalasia and outcomes over time. |
Inflammatory Bowel Disease is associated with an Increased Risk of Incident Acute Arterial Events: Analysis of the United Kingdom Biobank. In a prospective cohort, there was an increased risk of incident AAEs and premature AAEs in IBD participants. Beyond traditional AAE risk factors, quantifiable indices of IBD disease activity and severity were independent predictors of AAEs. |
Measuring Medication Use, Obstacles and Knowledge in Individuals with Cirrhosis. In a large, diverse cohort, we validated the My Cirrhosis Coach which can serve to standardize medication use and knowledge measurement in clinical practice and education-based studies in cirrhosis. |
| Endoscopy |
The course of pain and dysphagia after radiofrequency ablation for Barrett's esophagus-related neoplasia. RFA treatment for BE-related neoplasia seems a significant burden for patients, and post-procedural symptoms should be taken into account when counseling patients before starting endoscopic eradication therapy. |
| Gastroenterology |
Context-dependent roles of Hes1 in the adult pancreas and pancreatic tumor formation. The results indicated that HES1 is not required for maintaining the adult pancreas under normal conditions, but is important for regeneration during recovery from pancreatitis; moreover, Hes1 plays different roles depending on the tumor condition. Our findings highlight the context-dependent roles of HES1 in the adult pancreas and pancreatic cancer. |
| Gastrointest Endosc |
Comparative Accuracy of Endosonographic shear wave elastography and Transcutaneous Liver Stiffness Measurement: A pilot study. EUS-SWE correlates well with liver histology, and is a safe and reliable diagnostic test for assessing liver fibrosis with accuracy comparable to VCTE. |
Endocytoscopy for assessing histologic inflammation in ulcerative colitis: development and prospective validation of the ELECT score (ErLangen Endocytoscopy in ColiTis). Endocytoscopic grading of inflammatory activity along a newly developed scoring systems enables real-time histology in UC patients and better predicts clinical outcome in UC patients than endoscopic remission. |
| Hepatology |
A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation. Consistent mucosal microbiota features associated with PSC, PSC-IBD and disease severity, irrespective of LT status, highlights the utility of investigating PSC and rPSC in parallel, and suggests that the impact of gut microbiota on post-transplant liver health should be investigated further. |
Characterization of Morreton Virus (MORV) as a Novel Oncolytic Virotherapy Platform for Liver Cancers. Our findings indicate that wild-type MORV is safe and can induce potent tumor regression via immune-mediated and immune-independent mechanisms in HCC and CCA animal models, without dose limiting adverse events. These data warrant further development and clinical translation of MORV as a novel oncolytic virotherapy platform. |
Identification of novel neutralizing determinants for protection against hepatitis C virus. We show how N-linked glycosylation motifs can trigger dramatic changes in HCV sensitivity to nAb independent of glycan occupancy. These findings aid understanding of HCV nAb evasion and rational vaccine design, as they can be exploited to stabilize the structurally flexible envelope proteins in an open conformation exposing important neutralization epitopes. Finally, this work resulted in a panel of highly fit cell culture infectious HCV recombinants. |
Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion. In conclusion, we propose a role for SMLR1 in the trafficking of VLDL from the ER to the Cis-Golgi complex. While this study uncovers SMLR1 as a new player in the VLDL assembly, trafficking, and secretion pathway, it also shows that NASH can occur with undisturbed glucose homeostasis and atheroprotection. |
Mortality in End Stage Liver Patients Above MELD 3.0 of 40. MELD 3.0 scores beyond 40 are associated with increasing waitlist mortality without adversely affecting post-transplant outcome. Uncapping the MELD score in waitlist candidates may lead to greater survival benefit from LT. |
Serum Biomarkers Correlated with Liver Stiffness Assessed in a Multi-center Study of Pediatric Cholestatic Liver Disease. Endoglin, IL-8, and MMP-7 significantly correlate with increased LSM in children with BA, while CTGF inversely correlates with LSM in A1AT; these biomarkers appear to enhance prediction of LSM beyond clinical tests. Future disease-specific investigations of change in these biomarkers over time and as predictors of clinical outcomes will be important. |
Single-cell Transcriptomics Uncovers Cellular Architecture and Developmental Trajectories in Hepatoblastoma. Our findings illustrate the cellular architecture and developmental trajectories of HB via integrative bulk and single-cell transcriptome analyses, thus establishing a resourceful framework for the development of targeted diagnostics and therapeutics in the future. |
| J Hepatol |
Incidence and factors predictive of recurrent thrombosis in patients with non-cirrhotic portal vein thrombosis. No clinical or biochemical parameters predicted overall-RT. However, in the 48 patients with additional comprehensive thrombophilic study, factor VIII = 150% was the only independent factor predicting overall-RT (HR 7.10 (CI 2.17 - 23.17) p 150%. |
Neutrophil extracellular traps contribute to liver damage and increase defective low-density neutrophils in alcoholic hepatitis. Neutrophils contribute to liver damage through increased NET formation which increases defective LDNs in AH. Alcohol induces neutrophil phenotype changes; HDNs are activated whereas LDNs are defective. Our findings provide mechanistic insights for therapeutic interventions in AH. |
Non-invasive tests for clinically significant portal hypertension after HCV cure. The results of our pooled analysis refute previous concerns that these tests are less accurate after the cure of hepatitis C virus (HCV) infection. We have developed diagnostic criteria that facilitate the personalized management after HCV-cure and allow for a de-escalation of care in a high proportion of patients, thereby decreasing disease burden. |
| Neurogastroenterol Motil |
The effects of loperamide on excitatory and inhibitory neuromuscular function in the human colon. Loperamide had no effect on excitatory neuromuscular function in human colonic circular muscle. These findings suggest that loperamide alters colonic function by acting primarily on inhibitory motor neurons, premotor enteric neurons, or via alternative non-opioid receptor pathways. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
| Clin Gastroenterol Hepatol |
| Gastroenterology |
| Hepatology |
Geographical similarity and differences in the burden and genetic predisposition of NAFLD. We also describe some special populations including patients with type 2 diabetes, lean patients, pediatric population, and patients with concomitant liver diseases. We discuss extrahepatic outcomes, patient-reported outcomes, and economic burden related to NAFLD. |
| J Hepatol |
Alcohol consumption and metabolic syndrome: Clinical and epidemiological impact on liver disease. This accumulating evidence showing independent, combined, and modifying effects of alcohol and metabolic factors on the onset and progression of chronic liver disease highlights the multifactorial background of liver disease in the population. The evidence suggests that more holistic approaches could be useful for risk prediction and for diagnostics and treatment planning. |
Mechanotransduction in the pathogenesis of nonalcoholic fatty liver disease. The downstream consequences of disrupted mechanical homeostasis likely contribute to the progression of NAFLD and promote the development of portal hypertension, cirrhosis, and hepatocellular carcinoma. Identification of molecular targets involved in pathogenic mechanotransduction will allow for the development of novel strategies to prevent the progression of liver disease in NAFLD. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
| Clin Gastroenterol Hepatol |
| Gastroenterology |
| Hepatology |
| J Hepatol |